Refolution of pharmaceutical freezers

Controlled rapid freezer for demanding products in the manufacture of pharmaceutical and biotechnological products in the temperature range from -30°C to  -120 °C.

Description PharmaBlastFreeze

In the pharmaceutical and biotechnology industry, the focus in the production and processing of many products is on the associated low-temperature storage and transport. This also directly involves the controlled and homogeneous freezing of these products. Various options are available for freezing (e.g. blast freezers or plate freezers). Lower and lower temperatures and higher cooling rates are required to ensure that the products are handled in line with quality and requirements,</p

The PharmaBlastFreeze is a freezer for pallets and large containers of pharmaceutical products. Thanks to its compact design and large interior, the PharmaBlastFreeze can accommodate various packaging materials and can therefore be used universally. In addition to products in bag systems, bottle systems can also be easily processed and products can therefore be frozen in all common packaging materials.</p

The flexibly adjustable temperature range of -30 °C to -120 °C also offers customers the option of using the system depending on product requirements and therefore being able to freeze different products with different requirements in a targeted manner.

In order to fulfil the current legal and regulatory requirements and offer a future-proof design, the system uses an innovative chiller from Mirai Intex with the refrigerant air R729. This means that there are no restrictions due to, for example, the F-Gas Regulation and no safety requirements, as only air is used. By using this innovative technology, a wide temperature range with high cooling rates can be achieved with a compact system footprint.</p

The interior of the system is made entirely of stainless steel and is therefore easy to clean and fulfils the high requirements of the pharmaceutical and biotechnological environment. Thanks to its compact design, the PharmaBlastFreeze can be installed in non-classified rooms or integrated into the sterile area. The control panel is mounted directly on the system, making it easy for the system operator to handle.</p

To control the process, the system is equipped with a corresponding automation and visualisation system. This system complies with FDA requirements in accordance with 21 CFR, Part 11, whereby all process-relevant data such as batch reports and temperature curves are printed out in the form of a process report or forwarded to a higher-level system.

Technical details of the PharmaBlastFreeze

  • Refrigeration technology

    At low temperatures, the proven water-cooled cold air chiller from Mirai Intex is used. This is characterised by high efficiency and reliability in this area. Thanks to the air refrigerant (R729), the system is environmentally friendly and there are no restrictions or regulations imposed by the EU F-Gas Regulation and REACH.

  • Maximum temperature flexibility

    Flexible adjustment of the chamber temperature from -30 °C to -120 °C with a temperature accuracy of ± 0.5 °C. The chiller provides a high cooling capacity throughout.

  • High freezing speed

    Each product has the same freezing conditions at all times thanks to the high air circulation rates. In addition, the system can store energy and discharge it at short notice to increase performance.

  • Security

    Safety is permanently ensured by a monitoring system that continuously monitors the temperature and condition of the product. The refrigerant air means that there are no hazardous operating materials in the system. In addition, there are no special requirements for the installation location.

    A robust system technology makes the PharmaBlastFreeze a fail-safe and reliable freezer.

Reliable, durable, efficient and safe for people and the environment!

Advantages of the PharmaBlastFreeze

  • Minimal space requirement

    The entire refrigeration system is located behind the product room, separating the technical area from the production area. With dimensions of 3465 x 2500 mm, the entire system has a compact footprint.

  • Reliable service

    The PharmaBlastFreeze  is state of the art and fulfils the highest safety standards. In addition to production, comprehensive project support is also provided. The entire project - from system planning and production at HOF to commissioning - is comprehensively supported on site by a project team. In addition, HOF is also available for transport and installation with training and annual service and maintenance units.

  • Software with pharmaceutical documentation

    For process control, the PharmaBlastFreeze is equipped with a visualisation system, the "HOF Freeze Viewer Professional". This system complies with FDA requirements in accordance with 21 CFR, Part 11. With this software specially developed by HOF, all process-relevant data such as batch reports and temperature curves can be printed out in the form of a process report or forwarded to a higher-level system. The respective recipes for the individual products can be created individually by the customer.

Your advantages at a glance


Air as a refrigerant is free of charge, free of regulations and safe. The systems are robust and specially designed for low temperatures.

High reliability
High reliability

Proven technology - Made in Germany. Low wear and low maintenance.


The process parameters can be freely selected using flexible temperatures with high power density.


Speed-controlled, most efficient technology with reduced load peaks in the electricity and cooling water network

Safe for people and the environment
Safe for people and the environment

Natural refrigerant without high pressures. Air as refrigerant and oil-free machine.

Low maintenance & durable
Low maintenance & durable

No leak test and an air-bearing compressor = no wear, no oil. High-quality system technology.

Oliver Fleischer

HOF Sonderanlagenbau GmbH

Oliver Fleischer · Head of Service / Head of development - department refrigeration technology

Mit Refolution gelingt die Zukunft der Nachhaltigkeit, gepaart mit Effizienz und Weitsicht.
Der Profi für die Zukunft.
Christian Berger

CSL Behring

Christian Berger · Global Director - Process and Technology Owner for Aseptic & Sterility

Refolution supported me in the technical verification of design and dimensioning of a Natural Refrigerant Cooling System for a new Freeze Dryer system.
I was very happy with the immediate support and competence of the Refolution Team. Thanks for your help.

Technical details & options

Technical information


  • - Clear dimensions for the product: LxWxH 1590 x 1300 x 1800 mm

    - Chamber temperature control range: -30°C to -120°C

    - Minimum chamber temperature: -120°C 

    - Maximum chamber temperature: -30°C

    - Room cooling (without product): +20°C to -80°C < 120 min

    - Integrated refrigeration system: with R729

    - Installation dimensions Pharma-Freeze: approx. 3465 x 2500 x 2720 mm

    - Weight Pharma-Freeze: approx. 1800 kg 

    - Cooling capacity at -60 °C (MC 20 C/W/D): 9.60 kW

  • - Kleinere Transportabmessungen auf Anfrage. Mindestgröße ca. 2440 x 2500 x 2720 mm

    Weitere Optionen folgen...

Our suitable services for your PharmaBlastFreeze

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